Scientists have discovered antibodies that stop bleeding
Biologists from the Medical Research Fund of the U.S. state of Oklahoma reported the discovery of a previously unknown antibody capable of minimizing blood loss of the human body in case of any damage, such as in the case of cut or stab wounds. The researchers argue that for heavy internal and external bleeding in the event of injuries and poor blood clotting protein histone responsible. Scientists were able to find specific antibodies capable of blocking the negative side effects of histone.
New technique can eventually lead researchers to create drugs that block the bleeding in the case of serious injury. Writing in the journal Nature Medicine team of scientists says that they have found in the case of sepsis (blood infection by harmful microorganisms) in the blood of mice instantly increased histone content. Later exactly the same conclusions were based on the analysis of blood primates and humans. "Under normal conditions, the protein is active in the nucleus of cells in the immediate vicinity of the location of DNA. It also affects the very double-stranded DNA.
When the cell is damaged, then histone is released into the blood, where the protein begins to destroy the walls of blood vessels, "- wrote the researchers. This feature, in some cases, lead to uncontrolled bleeding and accumulation of fluid in the tissues. When scientists discovered this destructive feature of the protein, then immediately began to search for a method to lock.
As a result, scientists have found a previously unknown type of multi-drop antibodies that block the protein. During the study, researchers found that patients with autoimmune diseases produce antibodies in the nuclei of their cells. Here again the same scientists demonstrated that the antibody produced as in laboratory mice and in primates and humans. Influencing organisms laboratory mice with sepsis with new antibodies researchers were able to stop toxic histones. In the near future, this method will be tested on humans. "We believe that these antibodies - a kind of adaptation in evolution. Millions of years ago, when people and animals are sick, they do not die of heart attacks, they were dying of infectious diseases," - said study leader Dr. Charles Esmon.
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